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Indication
Anovulatory infertility, Adjunct to IVF procedures and other assisted conception techniques
Adult Dose
Intramuscular Prepubertal cryptorchidism in males Adult: 500-4000 u injected 3 times wkly. Treatment should continue for 1-2 mth after testicular descent. Male infertility due to hypogonadotrophic hypogonadism Adult: 500-4000 u injected 2-3 times wkly. Anovulatory infertility Adult: Single dose of 5000-10,000 u. Up to 3 repeated injections of up to 5000 u each may be given within the following 9 days to prevent corpus luteum insufficiency. Delayed puberty associated with hypogonadism in males Adult: Male: Initially, 500-1500 u twice a wk titrated against plasma-testosterone concentration.
Contraindication
Hypersensitivity; precocious puberty, prostatic carcinoma or other androgenic dependent neoplasm. Pregnancy and lactation.
Mode of Action
Chorionic Gonadotrophin is a polypeptide hormone produced by the human placenta. It stimulates the production of gonadal steroid hormones by inducing interstitial cells (Leydig cells) of the testis to produce androgens and the corpus luteum of the ovary to produce progesterone.
Precaution
Discontinue therapy if signs of precocious puberty are seen in patients treated for cryptorchidism. Patients with cardiac or renal disease, epilepsy, migraine or asthma.
Side Effect
Headache, irritability, restlessness, depression, fatigue, oedema; precocious puberty, gynaecomastia; pain at Inj site; enlargement of preexisting ovarian cysts and possible rupture; arterial thromboembolism; shock; abdominal pain. Potentially Fatal: Ovarian hyperstimulation syndrome (OHSS).
Interaction
Interactions of Human chorionic gonadotrophin with other medicines have not been investigated; interactions with commonly used medicinal products cannot be excluded. Following administration, Human chorionic gonadotrophin may interfere for up to 10 days with the immunological determination of serum/urinary human chorionic gonadotropin (hCG), leading to a false positive pregnancy test. Incompatibilities: In the absence of compatibility studies, Pregnyl must not be mixed with other medicinal products.
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